|
Hepatitis C
|
0.020 |
Biomarker
|
disease |
BEFREE |
Above this threshold, a single-step POC HCV-RNA (S<sub>12</sub>) was also found un-dominated (ICER to S<sub>5</sub>=€3,297.50).
|
31786434 |
2020 |
|
Spinal Muscular Atrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Spinal Muscular Atrophy Therapies: ICER Grounds the Price to Value Conversation in Facts.
|
31778615 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of the transcription factor cAMP response element modulator (CREM) α promotes altered cytokine expression in SLE.
|
31653682 |
2019 |
|
Lupus Vulgaris
|
0.030 |
Biomarker
|
disease |
BEFREE |
cAMP Response Element Modulator α Induces Dual Specificity Protein Phosphatase 4 to Promote Effector T Cells in Juvenile-Onset Lupus.
|
31653682 |
2019 |
|
Lupus Erythematosus, Discoid
|
0.030 |
Biomarker
|
disease |
BEFREE |
cAMP Response Element Modulator α Induces Dual Specificity Protein Phosphatase 4 to Promote Effector T Cells in Juvenile-Onset Lupus.
|
31653682 |
2019 |
|
Lupus Erythematosus
|
0.030 |
Biomarker
|
disease |
BEFREE |
cAMP Response Element Modulator α Induces Dual Specificity Protein Phosphatase 4 to Promote Effector T Cells in Juvenile-Onset Lupus.
|
31653682 |
2019 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Universal germline gene panel testing was not cost-effective compared with universal tumour testing strategies (ICER, $2.4 million/LYS).
|
31595523 |
2020 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The ICER was most sensitive to uncertainty in the number of total avertable cardiovascular disease DALYs in the eligible population.
|
31537367 |
2019 |
|
Atrial Fibrillation
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
In cryptogenic strokes with subsequent AF detection, PELI1 and CREM showed overexpression (p = 0.017, p = 0.059, respectively), whereas in high-risk asymptomatic populations, all three genes showed potential to detect AF (p = 0.007, p = 0.007, p = 0.015).
|
31475302 |
2019 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.020 |
Biomarker
|
disease |
BEFREE |
Gene fusions of Ewing sarcoma breakpoint region 1 (EWSR1) with members of the cAMP response element-binding protein family (CREB) of transcription factors (CREB1, activating transcription factor 1 (ATF1), and cAMP response element modulator (CREM)) have been described in histopathologically diverse mesenchymal neoplasms such as AFH, hyalinising clear cell carcinomas of salivary glands, primary pulmonary myxoid sarcoma, and clear cell sarcoma.
|
31139520 |
2019 |
|
Histiocytoma, Angiomatoid Fibrous
|
0.020 |
Biomarker
|
disease |
BEFREE |
Gene fusions of Ewing sarcoma breakpoint region 1 (EWSR1) with members of the cAMP response element-binding protein family (CREB) of transcription factors (CREB1, activating transcription factor 1 (ATF1), and cAMP response element modulator (CREM)) have been described in histopathologically diverse mesenchymal neoplasms such as AFH, hyalinising clear cell carcinomas of salivary glands, primary pulmonary myxoid sarcoma, and clear cell sarcoma.
|
31139520 |
2019 |
|
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Gene fusions of Ewing sarcoma breakpoint region 1 (EWSR1) with members of the cAMP response element-binding protein family (CREB) of transcription factors (CREB1, activating transcription factor 1 (ATF1), and cAMP response element modulator (CREM)) have been described in histopathologically diverse mesenchymal neoplasms such as AFH, hyalinising clear cell carcinomas of salivary glands, primary pulmonary myxoid sarcoma, and clear cell sarcoma.
|
31139520 |
2019 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
This tumor acidosis induced Gprotein-coupled receptor-dependent expression of the transcriptional repressor ICER in tumor-associated macrophages that led to their functional polarization toward a non-inflammatory phenotype and promoted tumor growth.
|
30397348 |
2018 |
|
Inflammatory Bowel Diseases
|
0.120 |
Biomarker
|
group |
BEFREE |
Further, emerging evidence for CREM in IBD susceptibility suggests that CREM is a critical regulator of enteric inflammation and may have broad therapeutic potential as a drug target across intestinal inflammatory diseases.
|
30228239 |
2018 |
|
Clear Cell Sarcoma of Soft Tissue
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
One CCSST case (6.3%) was found to have EWSR1 and CREM rearrangements, and 4 of 6 CCSLGT cases (66.7%) had EWSR1 rearrangement, of which 2 (33.3%) showed ATF1 rearrangement and the other 2 cases (33.3%) showed CREB1 rearrangement.
|
30219084 |
2018 |
|
Adult Clear Cell Sarcoma of Soft Parts
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
One CCSST case (6.3%) was found to have EWSR1 and CREM rearrangements, and 4 of 6 CCSLGT cases (66.7%) had EWSR1 rearrangement, of which 2 (33.3%) showed ATF1 rearrangement and the other 2 cases (33.3%) showed CREB1 rearrangement.
|
30219084 |
2018 |
|
Childhood Clear Cell Sarcoma of Soft Parts
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
One CCSST case (6.3%) was found to have EWSR1 and CREM rearrangements, and 4 of 6 CCSLGT cases (66.7%) had EWSR1 rearrangement, of which 2 (33.3%) showed ATF1 rearrangement and the other 2 cases (33.3%) showed CREB1 rearrangement.
|
30219084 |
2018 |
|
Major Depressive Disorder
|
0.320 |
Biomarker
|
disease |
BEFREE |
For moderate and severe MDD, the cost-utility analysis indicated a 67% likelihood of health gains at higher costs following the stepped-care approach and 33% likelihood of health gains at lower costs, with a mean ICER of about €3,200 per QALY gained.
|
30216769 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.100 |
Biomarker
|
disease |
BEFREE |
The transcriptional factor, inducible cAMP early repressor/cAMP response element modulator (ICER/CREM), has been shown to be induced in Th17 cells and to be overexpressed in CD4<sup>+</sup> T cells from the patients with systemic lupus erythematosus (SLE).
|
30150402 |
2018 |
|
Atrial Fibrillation
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Hemizygous mice with a cardiomyocyte-specific overexpression of the human cAMP response element modulator (CREM) isoform IbΔC-X spontaneously develop AF on grounds of an arrhythmogenic substrate consisting of alterations in structure, conduction, and calcium handling.
|
30026696 |
2018 |
|
Malaria
|
0.010 |
Biomarker
|
disease |
BEFREE |
In a scenario of increasing pyrethroid resistance, the incremental expected cost per case of malaria averted is expected to increase compared with the base case (ICER: $192.12).
|
30014819 |
2018 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
EWSR1-CREM fusions have not been previously reported in CCC and have only rarely been reported in other tumors.
|
29975250 |
2018 |
|
Single tumor
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
An RREB1-MKL2 fusion product was identified in 19 tumors (90%), a single tumor (5%) had an EWSR1-CREM fusion product, and the remaining case lacked any known fusion gene by RNA Sequencing.
|
29912715 |
2018 |
|
Atrial Fibrillation
|
0.060 |
Biomarker
|
disease |
BEFREE |
Expression of cardiac K<sub>2P</sub> channels was quantified by real-time qPCR and immunoblot in mouse models of AF [cAMP-response element modulator (CREM)-IbΔC-X transgenic animals] or HF (cardiac dysfunction induced by transverse aortic constriction, TAC).
|
29881975 |
2018 |
|
Heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
Expression of cardiac K<sub>2P</sub> channels was quantified by real-time qPCR and immunoblot in mouse models of AF [cAMP-response element modulator (CREM)-IbΔC-X transgenic animals] or HF (cardiac dysfunction induced by transverse aortic constriction, TAC).
|
29881975 |
2018 |